Tec Kinases
نویسندگان
چکیده
منابع مشابه
Beyond calcium: new signaling pathways for Tec family kinases.
The Tec kinases represent the second largest family of mammalian non-receptor tyrosine kinases and are distinguished by the presence of distinct proline-rich regions and pleckstrin homology domains that are required for proper regulation and activation. Best studied in lymphocyte and mast cells, these kinases are critical for the full activation of phospholipase-C gamma (PLC-gamma) and Ca(2+) m...
متن کاملDrosophila Ring Canal Growth Requires Src and Tec Kinases
The identification of ring canal proteins and insight into ring canal biogenesis have been aided by characterization of a class of mutants in which the flow of cytoLynn Cooley Department of Genetics Yale Medical School New Haven, Connecticut 06520-8005 plasm into the oocyte is impaired (Robinson and Cooley, 1996). The ultimate phenotype of these mutants is striking: egg chambers produce drastic...
متن کاملTec Family Kinases Modulate Thresholds for Thymocyte Development and Selection
Tec family kinases are implicated in T cell receptor (TCR) signaling, and combined mutation of inducible T cell kinase (Itk) and resting lymphocyte kinase (Rlk)/Txk in mice dramatically impairs mature T cell function. Nonetheless, mutation of these kinases still permits T cell development. While itk(-)(/)- mice exhibit mild reductions in T cells with decreased CD4/CD8 cell ratios, rlk(-)(/)-itk...
متن کاملEssential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival.
Tec family kinases have important roles in lymphocytes; however, little is known about their function in monocytes/macrophages. In this study we report that Tec family kinases are essential for M-CSF (M-CSF)-induced signaling pathways that regulate macrophage survival. Compared with wild-type bone marrow-derived macrophage (BMM) cultures, Tec(-/-)Btk(-/-) BMM cultures displayed increased cell d...
متن کاملProtein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases.
Etk, also named Bmx, is a member of the Tec tyrosine kinase family, which is characterized by a multimodular structure including a pleckstrin homology (PH) domain, an SH3 domain, an SH2 domain, and a catalytic domain. The signaling mechanisms regulating Etk kinase activity remain largely unknown. To identify factor(s) regulating Etk activity, we used the PH domain and a linker region of Etk as ...
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ژورنال
عنوان ژورنال: Immunity
سال: 2000
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(00)80189-2